What level of B12 is dangerously high? If someone has been on any form of a supplement containing B12, it can leave the serum levels of B12 elevated for a long time afterwards. Fatigue, exhaustion, and lack of motivation. Research on the use of vitamin B-12 for specific activities and conditions shows: Heart and blood vessel disease. Diagnosis is by . BMC Health Serv. These include inflammatory bowel disease (Crohn's disease), various types of . Have been feeling generally unwell for quite a few years with a lot of joint pain,been suggested it could be fibromyalgia. Thank you for visiting nature.com. STIs are the most common cause of genital sores. Alcoholic cirrhosis and cobalamin metabolism. Unauthorized use of these marks is strictly prohibited. Conditions that can increase B12 level include: Liver disease (such as cirrhosis or hepatitis) Myeloproliferative disorders (for example, polycythemia vera and chronic myelogenous leukemia). Dis. J. Natl. Serefhanoglu S, Aydogdu I, Kekilli E, Ilhan A, Kuku I. Ann Hematol. When platelet levels are low, the blood does not clot well, and bleeding cannot be controlled following minor injuries. The site is secure. Vitamin B12 or folate deficiency anaemia - Causes - NHS Disclosures: No relevant conflicts of interest to declare. 11, 110 (2011). Between January 2007 and May 2015, 9,198 patients underwent at least 2 measurements of B12 in our center, excluding the intensive care and maternity units. The plasma vitamin B12 (B12) measurement is mainly conducted to detect vitamin B12 deficiency, but the incidental finding of elevated B12 is not uncommon1,2. Elevated plasma vitamin B12 concentrations are independent predictors of in-hospital mortality in adult patients at nutritional risk. Significantly Elevated Vitamin B12 Levels in Autoimmune Vitamin B12 deficiency: Symptoms, complications, and more As the study aimed at comparing persistent and non-persistent elevated B12, patients who had only the last measurement1000ng/L were excluded. In contrast, people with ALPS often have abnormally low levels of HDL (high density lipoprotein) and total cholesterol. The basis of this article is to discuss some of the more serious or problematic things that could be causing your high vitamin B-12. Google Scholar. The goal of treatment is to increase your vitamin B12 level: Treatment involves a shot of vitamin B12 once a month. Elevated plasma vitamin B12 has been associated with solid cancers, based on a single B12 measurement. official website and that any information you provide is encrypted Even though the title is "cause of high B-12, Role of Transcobalamin in High B-12 Without Supplementation, Role of Solid Tumors and Hepatitis in High B12 Without Supplementation, Role of Blood Cancers in High B12 Without Supplementation, Blood cancers in general can lead to an increase in B-12 levels due to an increased production of these TCN 1 and TCN 3 transcobalamin proteins. Newman, A. C. & Maddocks, O. D. K. One-carbon metabolism in cancer. "Chicken contains vitamin B12, plus other antioxidants and vitamins which support the immune system and aid digestion. Clin. They sometimes just are not aware of it. Arendt, J. F. B. Therefore, anything that raises TCN 1 and TCN 3 will lower the functional activity of B-12 by limiting the binding of B-12 to the TCN 2. Moreover, thyroid disease is often caused by autoimmune disease (Hashimoto's thyroiditis). High serum cobalamin in dysimmune and inflammatory diseases may be linked to an increase in TCB II during the acute phase of inflammation. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. So if you are finding high B-12 levels and elevated methylmalonic acid, you would want to supplement with B-12 until that methylmalonic acid goes down. Vitamin B-12 level test: Uses, normal ranges, and results Surgery that removes or bypasses the end of the small intestine. An association with autoimmune or hematological disorders was observed. Med. Of these patients, 10/26 (38%) had elevated ferritin levels secondary to liver disease, 7/26 (27%) malignancy/infection, 6/26 (23%) malignancy alone, 1/26 (4%) autoimmune disease, and 1/26 (4% . These entities are essentially comprised of solid neoplasms, haematological malignancies and liver and kidney diseases. Previous studies have chosen a variety of levels to represent high or very high B12 (pmol/l) levels. The two major types of lymphocytes are B cells and T cells, which are derived from pluripotent hematopoietic stem cells in the bone marrow. The authors declare no competing interests. The frequency of myeloid blood malignancy did not differ between the EN and NN groups, and chronic liver disease was more common in the EN group than in the NN group. This still can be the cause of high B-12 without supplementation but there could be other, more serious, reasons for this as well. What Do High B12 Levels Mean? - PA Relief Even though the title is "cause of high B-12 without supplementation," my experience helping people figure this out, they are taking B-12. Anemia - Vitamin B12-Deficiency Anemia | NHLBI, NIH Additionally, an increase in serum vitamin B12 can indicate lymphoproliferation in the form of ALPS caused by mutations in the FAS gene (ALPS-FAS). Pernicious anemia: MedlinePlus Medical Encyclopedia See, in many autoimmune conditions, there is the risk of malabsorption which can result in nutrient deficiencies as well, it is best to get the blood test done in a fasted state and have abstained from vitamin B12 supplementation for three days, a serum vitamin B12 test does not differentiate between active and inactive forms, vegetarians and vegans may be at increased risk of developing a vitamin B12 deficiency, autoimmune patients often have a defect in how their bodies break down and utilize certain nutrients, Tips for Navigating the Holidays with Hashimotos, 25 Healthy Recipes for Thanksgiving Dinner, Thanksgiving Blessings: How I Learned to be Grateful for My Autoimmune Disease, Five Cold Weather Tips for Arthritis Sufferers, How to Make Household Cleaner Non Toxic and Safe. This site needs JavaScript to work properly. National Library of Medicine Precipitation with PEG is an easy method to confirm the presence of ICs and to evaluate serum vitamin B12 levels in these patients. Scientific Reports (Sci Rep) Alcoholic liver disease is an example of a liver condition associated with high vitamin B12. LiveWell Labs Nutrition 100% Methylcobalamin Vegan B12 Drops. Pregnant and breastfeeding women may also need to be especially mindful of B12 levels. There were 256/688 men (37.2%), and the median time from T1 to the last hospitalization or consultation was 3.2 [1.55.2] years. Chem. Med. Most of these more serious causes are altering the transportation of B-12 via the transcobalamin transport proteins (more on this below). Int. The difference was linked to a more frequent occurrence of incident solid cancer in the EE group (p<0.001 compared with EN and NN groups), as the EN and NN groups did not differ (p=0.28). 2023 Cryptoguiding. Nutrients. Of these, 25(OH)D deficiency was observed in 1031 (70.6%) patients. - Randomly woke up one day last week with excessive swelling under ja Hi forum This site needs JavaScript to work properly. What autoimmune diseases cause high B12 levels? There is no consensus on the definition of high or elevated B12. In other words, about 1 in 5 patients will develop ALPS lymphoma by the time they are 40. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). These control patients defined the NN (normal/normal) group. Article Cappello, S. et al. Some causes can be explored with simple investigations (blood count, renal function evaluation, liver cytolysis and cholestasis parameters, and liver echography) but solid cancer exploration often requires imaging or endoscopic examinations. 25, 825837 (2019). So keep reading we are going to get into the details. Sometimes, these enlarged lymph nodes are confused with cancer of the lymph gland, or lymphoma. One of the main causes of increased vitamin B12 with liver disease is release . 49, 11 (2011). Kingma TJ, Bascoy S, Altaf MD, Surampudy A, Chaudhry B. Cureus. Only vitamin B12 bound to TC is available for cellular uptake and use as coenzymes for L-methylmalonyl-CoA mutase and methionine synthase that synthesize succinyl-CoA and methionine, respectively. You are using a browser version with limited support for CSS. Thus, 3 groups of patients were defined according to B12 status: EE (elevated/elevated), EN (elevated/normal) and NN. Clin. Sci. Methods: Serum B12 levels was measured in 115 patients with AITD (7 men . Then, the patients with B121000ng/L at T1 were split into 2 groups, those having B121000ng/L at T2 (EE group) and those having B12<1000ng/L at T2 (EN group). ---Significance of elevated cobalamin (vitamin B12) levels in blood--- Abstract "Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. ALPS-related autoimmunity uncommonly targets organs, leading to rare complications such as. Cases of Gaucher disease, systemic lupus, rheumatoid arthritis and Still's disease with high serum cobalamin have also been reported. Among these patients, plasma B121000ng/L at T1 were found in 344 patients without any known elevated-B12-related causes. The mean age of patients in this subgroup was 46.6 years. The analyses were carried out using GRAPHPAD Prism v6.01 (GRAPHPAD SOFTWARE, La Jolla, CA, USA) and R software (version 3.5.1, R-project.org, Vienna, Austria). What causes high vitamin B12 levels without supplements? High or supraphysiological serum B12 levels without supplementation have been associated with many pathological conditions including renal failure, haematological disorders, cancer, and hepatic or autoimmune diseases. Why is a vitamin B-12 level test useful? Therefore, malabsorption of vitamin B-12 is quite likely to occur in patients with CD. HC is a glycosylated serum protein of ~68kDa that is produced mainly by . Prev. Seijo, L. M. et al. Consequently, if elevated B12 levels are caused by some cancers, elevated B12 should persist as long as the cancer persists. They build public awareness of the disease and are a driving force behind research to improve patients' lives. Hypercobalaminemia (high serum vitamin B12 levels) is a frequent and underestimated anomaly. Baker, H., Leevy, C. B., DeAngelis, B., Frank, O. Never disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We anticipated this bias using a survival competing risk model with the death as the competing risk. Federal government websites often end in .gov or .mil. Thrombocytopenia occurs when the body attacks and destroys blood components called platelets. Methionine is a metabolic dependency of tumor-initiating cells. Vitamin B 12 also plays an important role in hematopoiesis and maintaining the integrity of the nervous system. 2014 Feb;36(1):92-7. doi: 10. . The exact function of this HC-bound vitamin B12 is unknown (holo-HC), but it is believed to be biologically unavailable to most cells. PubMed Central Pernicious Anemia: Definition, Symptoms, Causes & Treatment In patients with repeatedly high B12 levels, ICs were detected in approximately 25% of samples. GP60 Clinical utility of elevated vitamin B12 levels with a showed that the SIR of cancers was higher within the year following B12 measurement than in subsequent years16. Internet Explorer). This study included patients aged 18years and over, admitted to Angers University Hospital between January 2007 and May 2015. Such changes are usually not indicative oflymphoma. Now this doesn't necessarily explain the elevated B-12 levels but it does explain how one can be deficient in B-12 in the presence of higher serum B-12 levels. FOIA & Baker, E. R. Cobalamin (vitamin B12) and holotranscobalamin changes in plasma and liver tissue in alcoholics with liver disease. In some people, high levels of B12 may cause gastrointestinal problems such as bloating and diarrhea. The results of this study show for the first time that elevated concentrations of vitamin B12 found in ALPS patients were due to increased leukocyte (including lymphocytes) expression of HC. Sci Rep 11, 13361 (2021). What vitamin Am I lacking if my joints hurt? The following general data were collected: sex, age, B12 levels, dates of B12 measurement, and death date. The prognostic nature of elevated B12 in solid cancers suggested the question of a possible link with the tumor mass or the capacity for proliferation20. B-12 can be released from the cells because basically it is where most of the B-12 is stored. Cite this article. What is it called when a prisoner goes back to jail? Autoimmune disease, especially against blood cells; . Med. Med. A certain type of vitamin B12 may be given through the nose. The diagnosis of ALPS is based on clinical findings, laboratory findings, and identification of mutations in genes, such as FAS, that affect the programmed destruction of cells (apoptosis). The patients with elevated plasma B12 at first measurement were split into 2 groups, according to the presence (EE group, n=144) or the absence (EN group, n=200) of persistent elevated plasma B12 at second measurement. & Olesen, F. Time intervals from first symptom to treatment of cancer: a cohort study of 2,212 newly diagnosed cancer patients. contributed to analysis and interpretation of data and critically revised the manuscript for important intellectual content. Brousselle, A. et al. Follow-up was limited at 60months. On the contrary, elevated B12 levels encountered in some cancers could be correlated with the tumor mass or the granulocytic immune response5,6,20. Cancer 49, 21872198 (2013). Implications cliniques de la dcouverte dune hypervitaminmie B12 en mdecine interne. J. Gastroenterol. General. Biochem. Nevertheless, the bulk of the study data came from the university hospital, which is the main healthcare facility in the region, so the risk of information loss appears to be reduced and is not biased between the groups. Screen. The cancer-free survival significantly differed between the 3 groups (p<0.001, Fig. Tingling sensation or Numbness In some patients, tingling sensation is experienced mostly in the right side of the body. Interne 29, 187194 (2008). Pearls and pitfalls in nonalcoholic fatty liver disease: tricky results are common. 2022 Oct 25;14(21):4476. doi: 10.3390/nu14214476. Reduce the amount of animal-derived foods that appear in your diet, as they contain vitamin B12. Subacute Combined Degeneration of the Spinal Cord: A Consequence of Recreational Nitrous Oxide Use. Conclusions: People with ALPS have an increased risk of developing lymphoma. The same thing happens with liver disease whether it is acute or chronic hepatitis. At home treatment didnt help (internally) but did soothe my skin Hi everyone. Separate from kidney disease, inflammation can be another cause for elevated B-12 levels. While spleen enlargement can be severe in children with ALPS,splenic rupture is very rare. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Provided by the Springer Nature SharedIt content-sharing initiative. Causes Of High B12 Without Supplementation, In this article we will discuss the causes of high B-12without supplementation. Size exclusion chromatography was employed to demonstrate the presence of immune complexes (ICs) with plasma vitamin B12-binding proteins in some serum samples with high B12. J. Arendt, J. F. B. 5, 2 (2016). Bethesda, MD 20894, Web Policies This supports the presence of undiagnosed subclinical cancer rather than a hypothetical role of the elevated B12 in the development of cancer. Vitamin B12 in Leber hereditary optic neuropathy mutation carriers: a prospective cohort study. A codified approach is needed to determine the potential indications of a search for high serum cobalamin and the practical clinical strategy to adopt upon discovery of elevated cobalamin levels. NCI CPTC Antibody Characterization Program. In a previous video we talked about What Does A High B-12 Level Mean and some things to think about with that. Among the causes of elevated B12, incident myeloid blood malignancies and chronic liver diseases were more frequent in the EE group (p<0.001 and p<0.001, respectively). Events only referred to solid cancers and not to blood malignancies. J. Complications. An unexplained elevated B12 level should be confirmed later by a second measurement, which could help to identify patients in whom the screening for solid cancers would be of interest. Serum Vitamin B12 was increased in 1186 (81.2%) patients, mainly middle-aged males, with sepsis, multiorgan failure, and higher 30-day mortality (all p < 0.01). Immune complexes; pernicious anemia; transcobalamin; vitamin B12. 10. However, a falsely normal or high value of vitamin B12 in the blood may occur if antibodies interfere with the test. Autoimmune hepatitis is when the body attacks the liver, an important organ that has many functions. McMahon, G. M. et al. 1, 37 In the aformentionned study from Arendt, high serum cobalamin levels were significantly associated with alcoholism (odds ratio (OR) = 5.74 [2.76-11.96], liver disease (OR = 8.53 [3.59-20.23]) and cancer (OR = 5.48 [2.85 . To date, the mechanism of the elevated vitamin B12 concentrations in ALPS patients has not been determined and we sought to explore the source of elevated vitamin B12. Both of which would be elevated in the presence of B-12 deficiency. How is vitamin B12-deficiency anemia treated? Med. Solid cancers and metastases sites are presented in Table S1, supplemental material. The influence of covariate (including age, sex, and all the elevated-B12-related causes) on the occurrence of solid cancer was evaluated with a survival competing risk model (package cmprsk from R) with the death as the competing risk. Med. These results could help to select patients in whom the screening for solid cancers would be of interest. Clin. Uveitis (inflammation of the iris in the eye). What can I invest 20 dollars in to make money? Would you like email updates of new search results? A low level of vitamin B12 in the blood indicates pernicious anemia. The proportion of men was higher in the EE group, but with no significant difference (p=0.06). High B-12 levels may indicate liver disease, diabetes, or another condition. Cancer Epidemiol. Significantly Elevated Vitamin B12 Levels in Autoimmune Lymphoproliferative Syndrome (ALPS), a Rare Lymphoproliferative DisorderLymphoproliferative DisorderLymphoproliferative disorders are a set of disorders characterized by the abnormal proliferation of lymphocytes into a monoclonal lymphocytosis. However, there is not enough evidence to recommend B12 supplementation to prevent heart . Our study has some limitations. These disease states result in an increased production of white blood cells including Granulocytes. V.L. Hansen, R. P., Vedsted, P., Sokolowski, I., Sndergaard, J. The age of the patients was similar in the 3 groups (Table 1). Lymphoproliferative disorders are a set of disorders characterized by the abnormal proliferation of lymphocytes into a monoclonal lymphocytosis. Not getting enough vitamin B12 to the point of a deficiency can cause a variety of serious symptoms including depression, joint pain, and fatigue. Unauthorized use of these marks is strictly prohibited. Clipboard, Search History, and several other advanced features are temporarily unavailable. At least one cause of elevated B12 was diagnosed in the follow-up of 75/144 (52.1%) patients in the EE group, 34/200 (17.0%) in the EN group, and 38/448 (11.0%) in the NN group (p<0.001, Table 1). False increased vitamin B12 levels in autoimmune gastritis and subacute HHS Vulnerability Disclosure, Help Solid cancers represent one of the main diagnoses found in patients with unexplained and persistent elevated B12. This can lead to elevated B-12 levels due to poor uptake of B-12 in the liver cells. and transmitted securely. Patients with elevated plasma B12 (1000ng/L) at first measurement (n=344) were matched for age and sex with patients having 2 normal B12 measurements (<1000ng/L) (NN group, n=344). J. Haematol. All patient records have been fully reviewed. In patients with repeatedly high B12 levels, ICs were detected in approximately 25% of samples. In the case that you've ruled out excess consumption of B-12, it makes sense to explore some of these other things. Gimsing, P. Cobalamin forms and analogues in plasma and myeloid cells during chronic myelogenous leukaemia related to clinical condition. 2. NIAID scientists also found that people with ALPS-FAS tend to have much higher B12 levels than do healthy people without this condition. J. Immune complexes and persistent high levels of serum vitamin B12 A positive ANA test means that you have high levels of ANA in your blood. The https:// ensures that you are connecting to the . In the case of incidental finding of elevated B12, the relevance of an active search for solid cancer necessitating invasive and expensive examinations remains debated5,18,19. Raffick AR Bowen, MLT, PhD, DClChem, FCACB, DABCC. B12 at T1 was higher in the EE group than in the EN group (p<0.001). The categorical data were presented as absolute values and as percentages and were compared using Chi-squared test. hbspt.cta._relativeUrls=true;hbspt.cta.load(119382, 'ab73c5a4-6cc2-47ae-89ec-692921a42cf5', {"useNewLoader":"true","region":"na1"}); Southwest Integrative Medicine 4045 East Bell Road Phoenix, AZ 85032 480.451.5407. Vitamin B12 - Critically Important but Often Not Diagnosed or Treated The pathophysiology of elevated vitamin B12 in clinical practice An association between elevated B12 and solid cancers has been demonstrated by two population-based cohort studies16,17 and persists after adjustment for the other elevated-B12-related causes1. B-12 uses three different carrier proteins to do this TCN 1, TCN 2, and TCN 3. So taking all those causes of elevated B-12 level into consideration, the first thing you want to do is find out if you're actually deficient in B-12. Vitamin B12 also plays an important role in hematopoiesis and maintaining the integrity of the nervous system. What stocks should I buy in a bear market? The incidence of solid cancers in the EE group argues for checking the persistence of B12 elevation to justify investigations in case of incidental finding of B12 elevation. The tests were carried out on an immunoanalytical system ADVIA Centaur (SIEMENS HEALTHCARE DIAGNOSTICS Inc. Tarrytown, NY, USA) with ADVIA Centaur VB12 reagents. Actually I now am like most people with autoimmune diseases because the test showed me deficient. Condoms are the most effective way to prevent HIV and STDs. The hazard ratios (HR) were presented with a confidence interval of 95%. Hi everyone. Increased vitamin B12 serum may be due to: Didn't find the answer you were looking for? Zibold J, von Livonius B, Kolarova H, Rudolph G, Priglinger CS, Klopstock T, Catarino CB. By using this Site you agree to the following, By using this Site you agree to the following, Need relief - not sure what is going on - std or autoimmune, Had IV Infusion for possible MS, test results unclear, The Best IOL for 2022 RXSight Light Adjusted Lens, Will refractive surgery such as LASIK keep me out of glasses all my life. The 344 patients in the NN group were randomly selected from the 7,889 patients with plasma B12<1000ng/L at T1 and T2. Can Rheumatoid arthritis cause elevated B12? Moreover, a prospective study was carried out during three consecutive months. In any case of persistently elevated B-12 levels, you should be explored the other things noted above with preliminary labs to make sure you don't have problems with your white blood cells, kidneys, liver, etc. J Clin Med. What causes high vitamin B12 levels without supplements? C.L., A.G., O.C., A.P. Risk of gastric adenocarcinoma increases 3-fold. Gimsing, P. Cobalamin metabolism in chronic myelogenous leukemia. Introduction: My name is Lakeisha Bayer VM, I am a brainy, kind, enchanting, healthy, lovely, clean, witty person who loves writing and wants to share my knowledge and understanding with you. BMC Nephrol. . This raises the question of the potential interest in repeating investigations 1year later. Compared to the NN group, a persistent elevated plasma B121000ng/mL was strongly associated with the occurrence of solid cancer (HR 5.90 [95% CI 2.7912.45], p<0.001), contrary to non-persistent plasma B12 elevation (p=0.29). J. Haematol. High or supraphysiological serum B12 levels without supplementation have been associated with many pathological conditions including renal failure, haematological disorders, cancer, and hepatic or autoimmune diseases. An official website of the United States government. When I was initially hospitalised in 2014, I showed a reading of 1353 (with 200-900 being the normal . Green, R. et al. Google Scholar. This one will focus on steps to take, labs to do etc. Epub 2019 Sep 23. The proportional hazard assumption was checked with 2 different methods: graphically by plotting the log(minuslog) curves and by studying the interaction with time. Background and objectives: In Crohn's disease (CD), belonging to inflammatory bowel disease, the small intestine is involved in most cases. Karin Amrein, Mario Scherkl, Oliver Malle, Arash Shirvani, Tyler Arek Kalajian, Michael F. Holick, Armin Zittermann, Heiner K. Berthold & Stefan Pilz, Astrid Lipplaa, Ricardo Fernandes, Pippa G. Corrie, Deirdre K. Tobias, Aditi Hazra, Samia Mora, Visalini Nair-Shalliker, Albert Bang, David P. Smith, M. Rebecca Heiner-Fokkema, Ineke J. Riphagen, Wilhelmina H. A. de Jong, Agustina A. M. B. Hastuti, Marta Costas-Rodrguez, Frank Vanhaecke, Scientific Reports (Video) What Does It Really Mean If You Have High B12 Levels? IUBMB Life 68, 303310 (2016). What happens when vitamin B12 is very high? Causes of High B12 Without Supplementation in Clinical Practice ). We know that where there is one autoimmune disease, others can be present. Br. In this study, characteristic of patients with serum vitamin B12 levels higher than 2500 pmol/L (high B12) were studied. Thus, doctors should monitor patients with ALPS for symptoms of lymphoma, such as night sweats, fever, fatigue, weight loss, loss of appetite, and sudden lymph node enlargement. Basophils are a type of white blood cell that have some role in immune surveillance (such as detecting and destroying very early cancers) and wound repair. FOIA Strength of the association of elevated vitamin B12 and solid cancers: An adjusted case-control study. That sounds like an oxymoron, "you're saying you're high in B-12 but you're actually deficient? 17, 235238 (1998). This is interesting for also exploring the other causes related to elevated B12. The word "pernicious" means gradually harmful and damaging. Pale or yellowish skin. Wolffenbuttel BHR, Muller Kobold AC, Sobczyska-Malefora A, Harrington DJ. The information in the article is based a research paper that can be found here ( Causes of High B12 Without Supplementation in Clinical Practice ). High prevalence of vitamin B-12 insufficiency in patients with - PubMed Cancer 116, 14991504 (2017). Does anyone have extremely high B12 levels? CAS Further studies are needed to elucidate the mechanism for the increased synthesis and secretion of HC from lymphocytes of ALPS patients, but altered cytokine profiles, including increased interleukin-10 levels in ALPS may contribute. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. 2). Prevalence of high B12 was evaluated during a 10-month period. With liver cancer some of the liver cells are damaged as a result the liver cell are are not expressing as many B-12 receptors. High serum concentration of cobalamin is a common but underestimated finding. What autoimmune diseases cause high B12 levels? (2023) . Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer, https://doi.org/10.1038/s41598-021-92945-y.
